Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells

Joëlle El Hajj , Eric Nguyen , Qingyuan Liu (1) , Claire Bouyer (2) , Eric Adriaenssens (3) , George Hilal , Evelyne Ségal-Bendirdjian (4)

1 IPHC - Institut Pluridisciplinaire Hubert Curien
2 UMR GMA - Unité de Génétique Moléculaire Animale
3 Signalisation des Facteurs de Croissance Dans Le Cancer du Sein . Proteomique Fonctionnelle
4 UPD5 - Université Paris Descartes - Paris 5

Background: Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators. Retinoids are well-known inducers of granulocytic maturation associated with hTERT repression in acute promyelocytic leukemia (APL) blasts. In a maturation-resistant APL cell line, we have previously identified a new pathway of retinoid-induced hTERT transcriptional repression independent of differentiation. Furthermore, we reported the isolation of a cell variant resistant to this repression. Those cell lines could serve as unique tools to identify new telomerase regulators.

Domaines: Cancer; Pharmacologie; Biologie moléculaire

Joëlle El Hajj, Eric Nguyen, Qingyuan Liu, Claire Bouyer, Eric Adriaenssens, et al.. Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells. Molecular Cancer, 2018, ⟨10.1186/s12943-018-0835-8⟩. ⟨hal-02390317⟩