Cerebral Peritumoral Oedema Study: Does a Single Dynamic MR Sequence Assessing Perfusion and Permeability Can Help to Differentiate Glioblastoma from Metastasis?

Pierre Lehmann (1) , Guillaume Saliou , Giovanni de Marco (2) , Pauline Monet (3) , Souraya Stoquart-Elsankari , Alexis Bruniau , Jean-Noël Vallée , Denis Ducreux (4)

1 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies
2 CeRSM - Centre de Recherche sur le Sport et le Mouvement
3 Service de radiologie
4 Stéroides et système nerveux : physiopathologie moléculaire et clinique

Our purpose was to differentiate glioblastoma from metastasis using a single dynamic MR sequence to assess perfusion and permeability parameters. 24 patients with glioblastoma or cerebral metastasis with peritumoral oedema were recruited and explored with a 3T MR unit. Post processing used DPTools software. Regions of interest were drawn around contrast enhancement to assess relative cerebral blood volume and permeability parameters. Around the contrast enhancement Glioblastoma present high rCBV with modification of the permeability, metastasis present slight modified rCBV without modification of permeability. In conclusion, peritumoral T2 hypersignal exploration associating morphological MR and functional MR parameters can help to differentiate cerebral metastasis from glioblastoma.

Mots clés: MR; Perfusion; Permeability; Glioblastoma; Metastasis

Domaines: Imagerie; Biomécanique [physics.med-ph]; Physiologie [q-bio.TO]

Pierre Lehmann, Guillaume Saliou, Giovanni de Marco, Pauline Monet, Souraya Stoquart-Elsankari, et al.. Cerebral Peritumoral Oedema Study: Does a Single Dynamic MR Sequence Assessing Perfusion and Permeability Can Help to Differentiate Glioblastoma from Metastasis?. European Journal of Radiology, 2012, 81 (3), pp.522-527. ⟨10.1016/j.ejrad.2011.01.076⟩. ⟨hal-01467324⟩