A Comparative Study of Perfusion Measurement in Brain Tumours at 3 Tesla MR : Arterial Spin Labeling versus Dynamic Susceptibility Contrast-Enhanced MRI

Abstract : PURPOSE: To prove the feasibility of arterial spin labeling (ASL) to explore brain tumors by comparing dynamic susceptibility contrast-enhanced MRI to ASL at 3T MR. MATERIALS AND METHODS: Twenty-seven patients were included presenting 9 gliomas, 10 metastases and 8 meningiomas. All were explored by a pseudo-continuous ASL and dynamic susceptibility contrast-enhanced T2* perfusion sequence. Two neuroradiologists analyzed the cerebral blood flow (CBF) maps to assess feasibility, examination quality and quantitative comparison. The Spearman nonparametric correlation test and the Bland-Altman graphic test were used to analyze our quantitative results. RESULTS: 92% of ASL CBF maps were informative. ASL detected all lesions as well as dynamic susceptibility contrast-enhanced MRI. Both sequences provide relative quantitative CBF values closely correlated. CONCLUSION: On a 3T MR unit, ASL is a good alternative to dynamic susceptibility contrast-enhanced MRI when contrast medium is contraindicated or intravenous injection is not possible. Its results on relative CBF parameters are similar to contrast-injected perfusion.
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Pierre Lehmann, Pauline Monet, Giovanni Marco, Guillaume Saliou, Muriel Perrin, et al.. A Comparative Study of Perfusion Measurement in Brain Tumours at 3 Tesla MR : Arterial Spin Labeling versus Dynamic Susceptibility Contrast-Enhanced MRI. European Neurology, Karger, 2010, 64 (1), pp.21-26. ⟨10.1159/000311520⟩. ⟨hal-01469470⟩

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