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Does Personality Disorder Co-Morbidity Impact Treatment Outcome for Patients with Major Depression? A Multi-Level Analysis

Abstract : In literature, there exists disagreement regarding the impact of comorbid personality disorder(s) (PD[s]) on treatment outcome for patients with major depressive disorder (MDD). The aim of this paper was to investigate whether statistical heterogeneity and inter-dependency are potential moderators of the effect of co-morbid PDs on outcome for patients with MDD. Clinician-rated MADRS scores and DSM-IV Axis II personality disorder diagnoses were obtained from 562 outpatients with MDD who received 6 months of combined psycho- and pharmacotherapy. Single-level regression showed significantly worse treatment outcome among patients with co-morbid PD, as compared to patients with no PD. After controlling for statistical heterogeneity and interdependency, treatment outcome was no longer significantly worse for patients with co-morbid PD. In conclusion, heteroscedasticity and inter-dependency should be considered as potentially compelling explanations for inconsistencies in findings on treatment outcome for depressed patients with co-morbid PDs.
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https://hal-univ-paris10.archives-ouvertes.fr/hal-01469893
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Submitted on : Thursday, February 16, 2017 - 6:39:30 PM
Last modification on : Tuesday, November 19, 2019 - 10:06:24 AM

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Filip de Fruyt, Lena C. Quilty, Jean-Pierre Rolland, Mieke Decuyper, R. Michael Bagby, et al.. Does Personality Disorder Co-Morbidity Impact Treatment Outcome for Patients with Major Depression? A Multi-Level Analysis. Journal of Personality Disorders, Guilford Press, 2011, 25 (1), pp.1-15. ⟨10.1521/pedi.2011.25.1.1⟩. ⟨hal-01469893⟩

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