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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Amarnath Rambhatla, Rupin Shah, Imad Ziouziou, Priyank Kothari, Gianmaria Salvio, et al.. Global Practice Patterns and Variations in the Medical and Surgical Management of Non-Obstructive Azoospermia: Results of a World-Wide Survey, Guidelines and Expert Recommendations. The World Journal of Men's Health, 2024, 42, ⟨10.5534/wjmh.230339⟩. ⟨hal-04569819⟩
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Nicolas Jovanovic, Vicente Mustieles, Marc Althuser, Sarah Lyon-Caen, Nadia Alfaidy, et al.. Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy. Human Reproduction Open, 2024, 2024, ⟨10.1093/hropen/hoae018⟩. ⟨hal-04569675⟩
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Géraldine Porcu-Buisson, Chloé Maignien, Nelly Swierkowski-Blanchard, Catherine Rongières, Noémie Ranisavljevic, et al.. Prospective multicenter observational real-world study to assess the use, efficacy and safety profile of follitropin delta during IVF/ICSI procedures (DELTA Study). European Journal of Obstetrics & Gynecology and Reproductive Biology, 2024, 293, pp.21-26. ⟨10.1016/j.ejogrb.2023.12.011⟩. ⟨inserm-04391221⟩
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Rossella Cannarella, Rupin Shah, Ramadan Saleh, Florence Boitrelle, Taha Abo-Almagd Abdel-Meguid Hamoda, et al.. Effects of Varicocele Repair on Sperm DNA Fragmentation and Seminal Malondialdehyde Levels in Infertile Men with Clinical Varicocele: A Systematic Review and Meta-Analysis. The World Journal of Men's Health, 2024, 42, ⟨10.5534/wjmh.230235⟩. ⟨hal-04402641⟩
References
2 231
Open Access
33 %
Keywords
Embryo
Reproduction
Fertility
Ovaire
Somatic cell nuclear transfer
Poulain
Humans
Mammary gland
Développement embryonnaire
Endometrium
Female
Animal models
Endomètre
Gestation
These
Ovary
Epigénétique
Sexual dimorphism
Uterus
Oocyte
Ruminant
Métabolisme
Jument
PLACENTA
Dna methylation
Blastocyst
Pregnancy
NUCLEAR TRANSFER
Oxidative stress
Transcriptome
IMMUNOLOGIE
Fetal programming
Progesterone
Goat
Development
Diesel
Alimentation
Male infertility
Animal model
Environment
Épigénétique
IMAGERIE
EMBRYO
Mice
Obesity
Nuclear transfer
Epigenetics
Souris
Adult
Epigenetic
Rabbit
DNA methylation
Sperm
Gene expression
BIOLOGIE DU DEVELOPPEMENT
Mare
Fertilité
Pluripotency
Sheep
DOHaD
Bovin
Dohad
Spermatozoa
Dairy cow
Obésité
Methylation
Infertility
GENETIQUE
Conceptus
Phénotype
Foxl2
Placenta
Male
Sex determination
Inflammation
Cattle
Développement
IMAGE
BIOTECHNOLOGIE
Horse
Meiosis
Embryon
Embryo transfer
Implantation
Nutrition
Chorion
Trophoblast
Foetus
Equine
Programmation foetale
Growth
Programming
GENOMIQUE
Mouse
Cheval
Spermatogenesis
Bovine
Méthylation
Animal modèle
Lapin